Serum levels of glucose-derived advanced glycation end products are associated with the severity of diabetic retinopathy in type 2 diabetic patients without renal dysfunction.

@article{Koga2002SerumLO,
  title={Serum levels of glucose-derived advanced glycation end products are associated with the severity of diabetic retinopathy in type 2 diabetic patients without renal dysfunction.},
  author={Kohachiro Koga and Sho-ichi Yamagishi and Tamami Okamoto and Yosuke Inagaki and Shinjiro Amano and Masayoshi Takeuchi and Z Makita},
  journal={International journal of clinical pharmacology research},
  year={2002},
  volume={22 1},
  pages={13-7}
}
Reducing sugars can react nonenzymatically with the amino groups of proteins to form Amadori products and subsequently cross-linked, heterogeneous fluorescent derivatives called advanced glycation end products (AGE). AGE can arise in vivo from various types of reducing sugars or dicarbonyl compounds and their formation and accumulation are known to progress during normal aging. In individuals with diabetes mellitus, this progression is greatly accelerated. The aim of the present study was to… CONTINUE READING
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