Serum levels of clozapine and norclozapine in patients treated with selective serotonin reuptake inhibitors.

@article{Centorrino1996SerumLO,
  title={Serum levels of clozapine and norclozapine in patients treated with selective serotonin reuptake inhibitors.},
  author={Franca Centorrino and Ross J. Baldessarini and FrancesR. Frankenburg and Judith C Kando and Sheila A. Volpicelli and James G. Flood},
  journal={The American journal of psychiatry},
  year={1996},
  volume={153 6},
  pages={
          820-2
        }
}
OBJECTIVE The selective serotonin reuptake inhibitor (SSRI) fluoxetine can increase serum levels of clozapine and norclozapine, but effects of other SSRIs are unknown. Thus, the authors evaluated interactions of clozapine with fluoxetine, paroxetine, and sertraline. METHOD Serum clozapine and norclozapine concentrations were assayed in 80 psychiatric patients, matched for age and clozapine dose, given clozapine (mean dose = 279 mg/day) alone or with fluoxetine (mean dose = 39.3 mg/day… CONTINUE READING
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