Serum levels of cartilage oligomeric matrix protein (COMP) correlate with radiographic progression of knee osteoarthritis.

@article{Vilm2002SerumLO,
  title={Serum levels of cartilage oligomeric matrix protein (COMP) correlate with radiographic progression of knee osteoarthritis.},
  author={Vladim{\'i}r Vil{\'i}m and Marta Olej{\'a}rov{\'a} and Stanislav Machacek and Jindři{\vs}ka Gatterov{\'a} and Virginia B. Kraus and Karel Pavelka},
  journal={Osteoarthritis and cartilage},
  year={2002},
  volume={10 9},
  pages={707-13}
}
OBJECTIVE To evaluate the prognostic utility of serum COMP level measured with a new sandwich ELISA, by correlating COMP level with outcome measures of osteoarthritis (OA) progression. DESIGN Patients (N=48) had symptomatic primary knee OA of Kellgren-Lawrence (K-L) grade I-III and met ACR criteria. These patients were evaluated prospectively as part of a double-blind drug trial of 3 years' duration and represented the placebo arm of the study. Serum COMP levels were measured by sandwich… CONTINUE READING

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