Serum levels of anticholinergic drugs in treatment of acute extrapyramidal side effects.

@article{Tune1980SerumLO,
  title={Serum levels of anticholinergic drugs in treatment of acute extrapyramidal side effects.},
  author={Larry E. Tune and Joseph T Coyle},
  journal={Archives of general psychiatry},
  year={1980},
  volume={37 3},
  pages={
          293-7
        }
}
A simple, sensitive, and specific radioreceptor assay has been developed for the measurement of anticholinergic drugs in human serum. The assay is based on the competitive inhibition by free anticholinergic drugs in a 0.2-mL sample of serum with the specific binding of the potent muscarinic antagonists, tritiated quinuclidinyl benzilate, to solubilized brain muscarinic receptors. Anticholinergic activity could be detected regardless of drug structure and was quantified against atropine… CONTINUE READING
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