Serum levels, absorption efficiency, faecal elimination and synthesis of cholesterol during increasing doses of dietary sitostanol esters in hypercholesterolaemic subjects.

  title={Serum levels, absorption efficiency, faecal elimination and synthesis of cholesterol during increasing doses of dietary sitostanol esters in hypercholesterolaemic subjects.},
  author={Hannu Vanhanen and Jaana Kajander and H Lehtovirta and Tatu A. Miettinen},
  journal={Clinical science},
  volume={87 1},
1. Serum cholesterol reduction and changes in cholesterol metabolism were studied during rapeseed oil feeding without and with increasing amounts of sitostanol trans-esterified with rapeseed oil fatty acids and dissolved in rapeseed oil mayonnaise. Fifteen mildly hypercholesterolaemic subjects replaced 50 g of their usual dietary fat by 50 g of rapeseed oil fat mayonnaise for 6 weeks followed by randomization so that eight subjects continued on rapeseed oil mayonnaise alone (control group) for… 
Serum sterols during stanol ester feeding in a mildly hypercholesterolemic population.
Plant stanol ester feeding lowers serum cholesterol in about 88% of subjects, decreases the non-cholesterol sterols that reflect cholesterol absorption, increases the sterols That reflect cholesterol synthesis, but also slightly increases serum plant stanols.
Cholesterol-lowering efficacy of a sitostanol-containing phytosterol mixture with a prudent diet in hyperlipidemic men.
Addition of blended phytosterols to a prudent North American diet improved plasma LDL-cholesterol concentrations by mechanisms that did not result in significant changes in endogenous cholesterol synthesis in hypercholesterolemic men.
Reduction of serum cholesterol with sitostanol-ester margarine in a mildly hypercholesterolemic population.
BACKGROUND Dietary plant sterols, especially sitostanol, reduce serum cholesterol by inhibiting cholesterol absorption. Soluble sitostanol may be more effective than a less soluble preparation. We
Serum, biliary, and fecal cholesterol and plant sterols in colectomized patients before and during consumption of stanol ester margarine.
Small amounts of plant stanols are recovered in serum and bile during consumption of stanol esters but effectively are secreted through bile, thereby balancing the intake-induced increase in their absorption.
Effects of phytosterol ester-enriched margarine on plasma lipoproteins in mild to moderate hypercholesterolemia are related to basal cholesterol and fat intake.
The improvements of LDL, HDL, total cholesterol, apolipoprotein B concentrations, and LDL/HDL cholesterol ratio during the daily consumption of a phytosterol ester-enriched margarine were most marked in those subjects with a high dietary intake of cholesterol, energy, total fat, and saturated fatty acids and with high baseline cholesterol absorption.
Short-term administration of tall oil phytosterols improves plasma lipid profiles in subjects with different cholesterol levels.
The results demonstrate the short-term efficacy of tall oil plant sterols as cholesterol-lowering agents and no difference was observed in cholesterol biosynthesis between tall oil and placebo treatments; however, the effect of treatments in subjects with different cholesterol levels varied.
Removal of intravenous Intralipid in patients with familial hypercholesterolemia during inhibition of cholesterol absorption and synthesis.
Despite the retarded removal of TRL lipids by STA and STE in the statin-treated subjects with FH, improvement of the fasting lipid profile was suggested important in consideration of combination of cholesterol absorption inhibitor with statins even in FH.
Regulation of cholesterol metabolism by dietary plant sterols.
Stanol ester margarine has been included in dietary treatment of hypercholesterolemia followed by the addition of drug treatment in resistant cases, and stanols and their esters are minimally absorbed and they reduce serum plant sterol concentrations, also preventing statin-induced increase of plant sterols.
Changes in serum level and metabolism of cholesterol with plant stanol esters in postmenopausal women with and without coronary artery disease
Plant stanol ester margarine consumption effectively reduced serum cholesterol in postmenopausal women with and without coronary artery disease in short-term and for at least 1 year in the noncoronary group, suggesting that stanol Ester Margarine might be used in the long-term for cholesterol lowering in women.
Nutrient Metabolism Free Phytosterols Effectively Reduce Plasma and Liver Cholesterol in Gerbils Fed Cholesterol 1
The potential of free phytosterols (including 20% stanols) to lower plasma and liver lipids was assessed in three experiments with gerbils fed diets containing cholesterol. The first explored the