Serum leptin concentrations in patients with anorexia nervosa, bulimia nervosa and non‐specific eating disorders correlate with the body mass index but are independent of the respective disease

  title={Serum leptin concentrations in patients with anorexia nervosa, bulimia nervosa and non‐specific eating disorders correlate with the body mass index but are independent of the respective disease},
  author={F Ferr{\'o}n and Robert Vincent Considine and Roberto Pein{\'o} and I. Lado and Carlos Di{\'e}guez and Felipe F. Casanueva},
  journal={Clinical Endocrinology},
OBJECTIVE Leptin, the product of the ob gene, is a recently discovered hormone secreted by adipocytes. Serum leptin concentrations increase in correlation with the percentage of body fat, but little else is known about the physiological actions of leptin in humans. The aim of this study was to determine the role of leptin in severe eating disorders, and whether its levels are correlated with the specific disease or exclusively with body weight. 
Opposite modifications in circulating leptin and soluble leptin receptor across the eating disorder spectrum
Results show, for the first time, that opposite modifications occur in circulating levels of leptin and Ob-Re across the eating-disorder spectrum.
Serum adiponectin and resistin concentrations in patients with restrictive and binge/purge form of anorexia nervosa and bulimia nervosa.
It is suggested that increased adiponectin levels reflect decreased body fat content in anorexia nervosa patients and circulating resistin levels do not appear to be closely related to the nutritional status.
Circulating leptin in patients with anorexia nervosa, bulimia nervosa or binge-eating disorder: relationship to body weight, eating patterns, psychopathology and endocrine changes
Since leptin was reduced in both underweight anorexics and normal weight bulimics, but increased in overweight BED women, who compulsively binge without engaging in compensatory behaviors, it is suggested that factors other than BW may play a role in the determination of leptin changes in eating disorders.
Decreased serum leptin in bulimia nervosa.
Results are consistent with the hypothesis that decreased leptin function may be associated with alterations in eating patterns, metabolic rate, and neuroendocrine regulation in bulimia nervosa.
Reduced plasma leptin concentrations in bulimia nervosa
This is the first known report of decreased plasma leptin levels in BN, and the decrement in leptin concentration is not related to BMI, body weight, or the presence or absence of BN.
Relationship of serum leptin levels and selected nutritional parameters in patients with protein-caloric malnutrition.
Serum leptin levels in patients with anorexia nervosa and short bowel syndrome are significantly lower than in healthy individuals and have no statistically significant relation to serum total protein, abumin, and prealbumin.
Leptin Secretion Is Related to Chronicity and Severity of the Illness in Bulimia Nervosa
Data show that leptin production is decreased in the subgroup of bulimic patients with a more chronic disease and with a greater severity of the bingeing/vomiting behavior, supporting the idea that factors other than body weight changes (especially chronic malnutrition and bingeing behavior) may impair profoundly and persistently leptin secretion in patients with BN.
Plamsa leptin response to acute fasting and refeeding in untreated women with bulimia nervosa.
In untreated women with BN, leptin, despite its very low plasma values, still holds its function as a sensor of body weight changes, but loses its role of signaling acute changes in energy balance.
The role of leptin in eating disorders - current views
Summary: Eating disorders constitute a dynamically developing group of diseases, in which only some have well-established diagnostic criteria, e.g. anorexia nervosa or bulimia nervosa. Many symptoms
Leptin, neuropeptide Y, and peptide YY in long-term recovered eating disorder patients
Alterations in NPY, PYY, and serum leptin concentrations are probably secondary to pathological eating behaviors and are unlikely to be trait-related disturbances that contribute to the etiology of eating disorders.


Serum immunoreactive leptin concentrations in patients with anorexia nervosa before and after partial weight recovery.
In conclusion, leptin levels are severely reduced in anorexia nervosa patients with severe malnutrition, and a significant rise occurred after partial weight recovery, there seems to be a level of BMI below which leptin levels do not drop further but also do not increase despite weight gain.
Steroids and neuroendocrine function in anorexia nervosa.
The results suggest that in anorexia nervosa the 11-beta-21-alpha-hydroxylase system is normal but a deficient 17-20 desmolaseSystem is present, and the altered pattern of GH secretion in anORExia was studied using GHRH (1 microgram/kg) as stimulus of pituitary GH secretion.
Serum immunoreactive-leptin concentrations in normal-weight and obese humans.
Serum leptin concentrations are correlated with the percentage of body fat, suggesting that most obese persons are insensitive to endogenous leptin production.
GHRH‐induced GH secretion in anorexia nervosa patients was similar to that in control subjects and in controls under oestrogen receptor blockade, and a small PRL peak at 15 min that was similar in the three groups tested.
Eating disorders
  • Carnall
  • Medicine
    International Journal of Obesity
  • 1999
Eating disorders mainly affect females but approximately one in ten individuals with an eating disorder is male. It is difficult to accurately estimate the frequency of occurrence of eating disorders
Overexpression of the obese (ob) gene in adipose tissue of human obese subjects
Investigation of human ob expression in subcutaneous and omental adipose tissue obtained from non–obese and massively obese subjects using in situ hybridization histochemistry and report on overexpression in obese people.
Effects of the obese gene product on body weight regulation in ob/ob mice.
The data suggest that the OB protein regulates body weight and fat deposition through effects on metabolism and appetite.
A practical guide to the treatment of bulimia nervosa.
  • C. Freeman
  • Psychology, Medicine
    Journal of psychosomatic research
  • 1991
Tackling things in the reverse order, addressing the underlying or background interpersonal difficulties first and paying little or no attention to the presenting behaviour appears to be less acceptable to patients, leads to lengthier and therefore more costly treatment and makes it difficult to distinguish between problems which are causes and those which are effects of the bulimic behaviour.
Behaviour therapy in anorexia nervosa.
There was no overall significant difference in weight gain in the two groups except in a subset of patients: those with no prior out-patient treatments.
Eating disorders in the DSM-IV.
The guiding principles and operating procedures of the Eating Disorders Work Group are described. Provisional diagnostic criteria for the 4th edition of the Diagnostic and Statistical Manual of