Serum leptin and age-related macular degeneration.

  title={Serum leptin and age-related macular degeneration.},
  author={Sudarshan Seshasai and Jiemin Liao and Qi Chun Toh and Ching-Yu Cheng and Gemmy Chui Ming Cheung and Sunil K. Sethi and Tien Yin Wong and Charumathi Sabanayagam},
  journal={Investigative ophthalmology & visual science},
  volume={56 3},
PURPOSE Leptin, a 167-amino acid protein secreted by adipocytes, has been shown to reduce beta-amyloid deposition and intracellular lipid concentration in animal models, two key pathogenic mechanisms underlying aging. We examined the association between serum leptin levels and AMD. METHODS We conducted a population-based case-control study including Chinese and Indian adults aged 40 to 80 years who participated in the Singapore Epidemiology of Eye Diseases Study (2007-2011). Age-related… CONTINUE READING
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