Serum interleukin-17 and its relationship to angiogenic factors in multiple myeloma.

@article{Alexandrakis2006SerumIA,
  title={Serum interleukin-17 and its relationship to angiogenic factors in multiple myeloma.},
  author={Michael G. Alexandrakis and Constantina A. Pappa and Spiros Miyakis and Aikaterini Sfiridaki and Maria Kafousi and Athanassios K Alegakis and Efstathios Stathopoulos},
  journal={European journal of internal medicine},
  year={2006},
  volume={17 6},
  pages={412-6}
}
BACKGROUND Interleukin-17 (IL-17) is a CD4 T-cell-derived mediator of angiogenesis that stimulates vascular endothelial cell migration and regulates the production of a variety of proangiogenic factors, such as tumor necrosis factor-alpha (TNF-alpha) and vascular endothelial cell growth factor (VEGF). Angiogenesis is implicated in the progression of multiple myeloma (MM). METHODS We measured serum levels of IL-17, TNF-alpha, and VEGF, as well as microvessel density (MVD) in 40 untreated MM… CONTINUE READING
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