Serum interferon-gamma-inducing factor/IL-18 levels in primary biliary cirrhosis.

  title={Serum interferon-gamma-inducing factor/IL-18 levels in primary biliary cirrhosis.},
  author={Toshihisa Yamano and Toshihiro Higashi and Kazuhiro Nouso and Harushige Nakatsukasa and Kazuya Kariyama and Eiji Yumoto and Yuko Kobayashi and Kazuhide Yamamoto and Hiromi Iwagaki and Takahito Yagi and Tadao Tanimoto and Masashi Kurimoto and Noriaki Tanaka and Takao Tsuji},
  journal={Clinical and experimental immunology},
  volume={122 2},
Primary biliary cirrhosis is an autoimmune disease of the liver in which T helper 1 cytokines predominate over those of T helper 2 in the pathogenesis. Interleukin- 18 (IL-18), for which the gene was recently cloned, is a novel T helper 1 cytokine, which augments interferon-gamma production. We designed this study to clarify the role of IL-18 in primary biliary cirrhosis and to examine whether serum IL-18 level can be a prognostic indicator for the disease. Serum IL-18 levels were measured… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 21 extracted citations

Similar Papers

Loading similar papers…