Serum insulin‐like growth factor I in a random population sample of men and women: relation to age, sex, smoking habits, coffee consumption and physical activity, blood pressure and concentrations of plasma lipids, fibrinogen, parathyroid hormone and osteocalcin

@article{LandinWllhelmsen1994SerumIG,
  title={Serum insulin‐like growth factor I in a random population sample of men and women: relation to age, sex, smoking habits, coffee consumption and physical activity, blood pressure and concentrations of plasma lipids, fibrinogen, parathyroid hormone and osteocalcin},
  author={Kerstin Landin‐Wllhelmsen and Lars Wllhelmsen and George Lappast and Thord Ros{\'e}n and G{\"o}ran Lindstedt and Per Arne Lundberg and Bengt-{\aa}ke Bengtsson},
  journal={Clinical Endocrinology},
  year={1994},
  volume={41}
}
OBJECTIVE There Is a cllnlcal need for population based reference values for serum Insulin‐like growth factor I (IGF‐I). We have therefore determined serum IGF‐i concentrations In a random population sample from Sweden and have related the levels to age, sex, llfe style factors, blood pressure, body composition, blood llplds, plasma fibrlnogen, Parathyroid hormone (PTH) and osteocalcin. 
Determinants of circulating insulin-like growth factor I and insulin-like growth factor binding protein 3 concentrations in a cohort of Singapore men and women.
TLDR
The results of this study lend additional support to the hypothesis that circulating IGF-I concentrations increase the risk of prostate, bladder, colorectal, and breast cancer.
Plasma concentrations of insulin-like growth factors among healthy adult men and postmenopausal women: associations with body composition, lifestyle, and reproductive factors.
  • Shine ChangXifeng WuHerbert YuM. Spitz
  • Medicine, Biology
    Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
  • 2002
TLDR
Whereas some traditional cancer risk factors were associated with IGF levels, altogether, they accounted for <15% of the total variability in plasma levels for each IGF, suggesting that other factors influence IGF levels.
Dietary fat and carbohydrates are independently associated with circulating insulin-like growth factor 1 and insulin-like growth factor-binding protein 3 concentrations in healthy adults.
TLDR
Serum IGF-1 and/or IGFBP-3 concentrations are associated with red meat, carbohydrate intake, and fat intake and, thus, may mediate the effect of these dietary factors on the pathogenesis of several disease states.
Lifestyle correlates of plasma insulin-like growth factor I and insulin-like growth factor binding protein 3 concentrations.
  • M. HolmesM. PollakS. Hankinson
  • Medicine, Biology
    Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
  • 2002
TLDR
The cross-sectional association of plasma IGF-I and IGF-binding protein 3 (IGFBP-3) levels with age, smoking, physical activity, and reproductive and menopausal factors in 1037 healthy women was examined to report the first report of an inverse association of circulating IGF- I levels with parity.
Insulin‐like growth factor‐1 is a predictor of blood haemoglobin concentration in 70‐yr‐old subjects
TLDR
GH and/or IGF‐1 are, independently from EPO and regardless of health status and sex, a significant determinant of Hb in elderly subjects.
Circulating Insulin-Like Growth Factor-1 and Its Binding Protein-3: Metabolic and Genetic Correlates in the Community
TLDR
The authors' cross-sectional observations in a large community-based sample link lower circulating IGF-1 to greater metabolic risk burden and underscore substantial genetic influences on IGF-2 concentrations, as well as investigating their relations to cardiovascular risk factors.
Dietary and lifestyle correlates of plasma insulin-like growth factor-I (IGF-I) and IGF binding protein-3 (IGFBP-3): the multiethnic cohort.
TLDR
A positive correlation was found between IGF-I levels (ng/mL) and colon cancer incidence rates (per 100,000) within the MEC by race/ethnicity for both sexes but not for either breast or prostate cancer.
Relationships between IGF-I and age, gender, body mass, fat distribution, metabolic and hormonal variables in obese patients
TLDR
In obesity, IGF-I concentrations are slightly reduced, but generally within the age-adjusted normal range, and are not associated with fat distribution, insulin secretion, glucose tolerance, BP or risk indices for cardiovascular disease (CVD).
Lifestyle determinants of serum insulin-like growth-factor-I (IGF-I), C-peptide and hormone binding protein levels in British women
TLDR
The data show that age is a major determinant of both IGF-I and its main binding proteins in women, and BMI has strong effects on IGFBPs, C-peptide, and SHBG, but its effects onIGF-I remain unclear.
Correlates of serum leptin and insulin-like growth factor-I concentrations in normal weight and overweight/obese Iranian women.
TLDR
The results indicated that the serum leptin and total IGF-I concentrations are differentially regulated in healthy normal weight and overweight/obese Iranian women.
...
...

References

SHOWING 1-10 OF 45 REFERENCES
Influence of physical activity on insulin-like growth factor-I in healthy younger and older men.
TLDR
The results suggest that lower levels of IGF-I in aging men are related at least in part to diminished physical activity, and multiple factors contribute to the age-related decline.
Growth hormone treatment of growth hormone-deficient adults results in a marked increase in Lp(a) and HDL cholesterol concentrations.
TLDR
The effects of growth hormone treatment of adults with adult-onset pituitary insufficiency on lipoproteins and apolipoproteins were investigated and high density lipoprotein cholesterol concentrations increased during treatment and were significantly higher than pretreatment levels after 26 weeks of treatment.
Age‐Related Alterations of the Growth Hormone/Insulin‐Like‐Growth‐Factor I Axis
  • M. Kelijman
  • Medicine, Biology
    Journal of the American Geriatrics Society
  • 1991
TLDR
The hypothesis that age-associated GH deficiency contributes to the aging process is hypothesis that GH replacement therapy in aging humans has become a feasible option.
Age and relative adiposity are specific negative determinants of the frequency and amplitude of growth hormone (GH) secretory bursts and the half-life of endogenous GH in healthy men.
TLDR
It is concluded that age and relative adiposity are distinct and specific correlates of individual attributes of GH secretion and clearance in men.
Effects of aging and sex on plasma insulin-like growth factor I (IGF-I) levels in normal adults.
TLDR
In both sexes, plasma IGF-I levels declined with age, and in females, the slope of the regression line was much steeper in the young group than in the middle-aged and elderly group (aged 41 to 80 years).
Human growth hormone and human aging.
TLDR
It may be justifiable initially to limit use of GH to certain elderly patients such as those suffering from catabolic illnesses, malnourishment, burns, cachexia, etc, but a great deal more research will be necessary to determine whether normalization of GH and IGF-I levels in healthy older persons will lead to improvements in their physical and psychological functional capacity and quality of life.
Impaired growth hormone secretion in the adult population: relation to age and adiposity.
TLDR
Within each decade, plasma SmC was inversely related to adiposity, and increased progressively from age 20 to 90: third decade, 0%; fourth, 11%; fifth, 20%; sixth, 22%; seventh, 42%; eight, 55%; and ninth, 55%.
Fibrinogen as a risk factor for stroke and myocardial infarction.
TLDR
Although causality cannot be inferred from these data, it is possible that the fibrinogen level plays an important part in the development of stroke and myocardial infarction.
Hormone and receptor studies: relationship to linear growth in childhood and puberty.
TLDR
GHBP, expressed as a percentage of the [125I]GH bound, increased yearly in males and females, with no relationship to the secretion of sex hormones, and exhibited a strong positive correlation with linear height.
Effects of sex and age on the 24-hour profile of growth hormone secretion in man: importance of endogenous estradiol concentrations.
TLDR
The results indicate that sex and age have independent and interrelated effects on GH secretion, and an amplifying action of estradiol on the neuroendocrine regulation of pulsatile GH release is suggested.
...
...