Serum hepatitis B surface antigen quantitation can reflect hepatitis B virus in the liver and predict treatment response.

@article{Chan2007SerumHB,
  title={Serum hepatitis B surface antigen quantitation can reflect hepatitis B virus in the liver and predict treatment response.},
  author={Henry L. Y. Chan and Vincent Wai-Sun Wong and Ada Tse and Chi-Hang Tse and Angel Mei-ling Chim and Henry Lik-Yuen Chan and Grace Lai-Hung Wong and Joseph J. Y. Sung},
  journal={Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association},
  year={2007},
  volume={5 12},
  pages={1462-8}
}
BACKGROUND & AIMS We aimed to evaluate serum hepatitis B surface antigen (HBsAg) quantitation as a surrogate marker for covalently closed circular DNA (cccDNA) and intrahepatic hepatitis B virus (HBV) DNA, and as a predictor of sustained virologic response to peginterferon and lamivudine combination therapy. METHODS Twenty-six hepatitis B e antigen-positive chronic hepatitis B patients receiving combination treatment of 32-week peginterferon alfa-2b and 2-year lamivudine were studied. All… CONTINUE READING

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