Serum ghrelin levels are inversely correlated with body mass index, age, and insulin concentrations in normal children and are markedly increased in Prader-Willi syndrome.

@article{Haqq2003SerumGL,
  title={Serum ghrelin levels are inversely correlated with body mass index, age, and insulin concentrations in normal children and are markedly increased in Prader-Willi syndrome.},
  author={A M Haqq and I Sadaf Farooqi and Stephen O'Rahilly and Diane D. Stadler and Ron G. Rosenfeld and Katherine L. Pratt and Stephen H Lafranchi and Jonathan Q Purnell},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2003},
  volume={88 1},
  pages={174-8}
}
Ghrelin, an endogenous ligand of the GH secretagogue receptor, stimulates appetite and causes obesity in animal models and in humans when given in pharmacologic doses. Prader-Willi Syndrome (PWS) is a genetic obesity syndrome characterized by GH deficiency and the onset of a voracious appetite and obesity in childhood. We, therefore, hypothesized that… CONTINUE READING