Serum gelatinase B/MMP-9 in primary progressive multiple sclerosis patients treated with interferon-beta-1a

@article{Dubois2003SerumGB,
  title={Serum gelatinase B/MMP-9 in primary progressive multiple sclerosis patients treated with interferon-beta-1a},
  author={PhD B{\'e}n{\'e}dicte Dubois and Siobhan M. Leary MRCP and Inge Nelissen and PhD Ghislain Opdenakker and Dr. Gavin Giovannoni and Alan J. Thompson},
  journal={Journal of Neurology},
  year={2003},
  volume={250},
  pages={1037-1043}
}
Interferon- beta (IFNβ) acts by a variety of mechanisms in relapsing-remitting multiple sclerosis (MS). One of these is a cellular down-regulation of gelatinase B or matrix metalloproteinase-9 (MMP-9), which is known from biochemical, biological and immunohistochemical evidences to play a disease-promoting role in MS. a) To investigate the influence of IFNβ-1a (30 or 60 µg I. M./week) on serum MMP-9 levels in patients with primary progressive MS (PPMS). b) To correlate serum MMP-9 levels with… CONTINUE READING