Serum-free culture success of glial tumors is related to specific molecular profiles and expression of extracellular matrix-associated gene modules.

@article{Balvers2013SerumfreeCS,
  title={Serum-free culture success of glial tumors is related to specific molecular profiles and expression of extracellular matrix-associated gene modules.},
  author={Rutger K. Balvers and Anne Kleijn and Jenneke J. Kloezeman and Pim J. French and Andreas Kremer and Martin J. van den Bent and Clemens M. F. Dirven and S. Leenstra and Martine L. M. Lamfers},
  journal={Neuro-oncology},
  year={2013},
  volume={15 12},
  pages={1684-95}
}
BACKGROUND Recent molecular characterization studies have identified clinically relevant molecular subtypes to coexist within the same histological entities of glioma. Comparative studies between serum-supplemented and serum-free (SF) culture conditions have demonstrated that SF conditions select for glioma stem-like cells, which superiorly conserve genomic alterations. However, neither the representation of molecular subtypes within SF culture assays nor the molecular distinctions between… CONTINUE READING
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