Serum factors involved in human microvascular endothelial cell morphogenesis.

@article{Harvey2002SerumFI,
  title={Serum factors involved in human microvascular endothelial cell morphogenesis.},
  author={Kevin A. Harvey and Rafat A. Siddiqui and Daniel Sliva and Joe G. N. Garcia and Denis English},
  journal={The Journal of laboratory and clinical medicine},
  year={2002},
  volume={140 3},
  pages={188-98}
}
Our previous studies have demonstrated that lipid and protein angiogenic factors operate in tandem to induce optimal angiogenic responses in vivo. This study was undertaken to clarify the nature of the substances in human serum that are responsible for its remarkable ability to promote capillary morphogenesis in vitro. The ability of dilute (2%) human serum to promote the morphogenic differentiation of human dermal microvascular endothelial cells on Matrigel supports was depleted by more than… CONTINUE READING