Serum evaluation of angiogenic cytokine basic fibroblast growth factor, hepatocyte growth factor and TNF-alpha in patients with myelodysplastic syndromes: correlation with bone marrow microvascular density.

@article{Alexandrakis2005SerumEO,
  title={Serum evaluation of angiogenic cytokine basic fibroblast growth factor, hepatocyte growth factor and TNF-alpha in patients with myelodysplastic syndromes: correlation with bone marrow microvascular density.},
  author={Michael G. Alexandrakis and Freda H Passam and Constantina A. Pappa and John Damilakis and George E Tsirakis and Ermioni Kandidaki and Andrew M Passam and Efstathios Stathopoulos and Despina S Kyriakou},
  journal={International journal of immunopathology and pharmacology},
  year={2005},
  volume={18 2},
  pages={287-95}
}
Recent studies have documented that angiogenesis plays a significant role in haematological malignancies, including mylodysplastic syndromes (MDS). Basic fibroblast growth factor (b-FGF), Hepatocyte growth factor (HGF) and Tumor necrosis factor-alpha (TNF-alpha) are multifunctional cytokines that potently stimulate angiogenesis. The aim of the present study was to evaluate the microvascular density (MVD) and the serum levels of these angiogenic factors in patients with myelodysplastic syndromes… CONTINUE READING

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