Serum erythropoietin measured by chemiluminescent immunometric assay: an accurate diagnostic test for absolute erythrocytosis.

@article{Mossuz2005SerumEM,
  title={Serum erythropoietin measured by chemiluminescent immunometric assay: an accurate diagnostic test for absolute erythrocytosis.},
  author={Pascal Mossuz and François Girodon and Sylvie Hermouet and Ir{\`e}ne Dobo and Eric Lippert and Magali Donnard and V{\'e}ronique Latger-Cannard and Nathalie Boiret and Vincent Praloran and Jean Claude Lecron},
  journal={Clinical chemistry},
  year={2005},
  volume={51 6},
  pages={
          1018-21
        }
}
Absolute erythrocytosis (AE), suspected from a high hemoglobin concentration and/or hematocrit, can be confirmed by an increased red cell mass (RCM) (1). Schematically, one distinguishes three major mechanisms of AE: (a) erythropoietin (Epo)-independent proliferation of clonal erythroid precursors as found in polycythemia vera (PV) and other myeloproliferative disorders; (b) Epo-dependent polyclonal proliferation of erythroid precursors as found in secondary erythrocytoses that are secondary to… CONTINUE READING
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