Serum enzyme activities and hepatic triglyceride levels in acute and subacute acetaminophen-treated rats.

@article{Buttar1976SerumEA,
  title={Serum enzyme activities and hepatic triglyceride levels in acute and subacute acetaminophen-treated rats.},
  author={H. Buttar and E. Nera and R. Downie},
  journal={Toxicology},
  year={1976},
  volume={6 1},
  pages={
          9-20
        }
}
The dose- and time-related hepatotoxic effects of acetaminophen were investigated in rats using biochemical parameters as indices of hepatotoxicity supplemented by the histopathological examination of the livers. The acute or subacute (twice daily for 7 days) administration of 0.25 g/kg acetaminophen did not produce any noticeable hepatocellular damage. On the other hand, dose-dependent elevations in serum enzyme glutamic-oxaloacetic transaminase (GOT), glutamic-pyruvic transaminase (GPT) and… Expand
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