Serum effect on cellular uptake of spermidine, spergualin, 15-deoxyspergualin, and their metabolites by L5178Y cells.

@article{Kunimoto1989SerumEO,
  title={Serum effect on cellular uptake of spermidine, spergualin, 15-deoxyspergualin, and their metabolites by L5178Y cells.},
  author={Setsuko Kunimoto and Chihiro Nosaka and Cheng Xu and Tomio Takeuchi},
  journal={The Journal of antibiotics},
  year={1989},
  volume={42 1},
  pages={116-22}
}
Spergualin (SG) and 15-deoxyspergualin (DSG) were more slowly incorporated into L5178Y cells than spermidine. SG and DSG inhibited carrier-mediated transport of [3H]spermidine competitively with inhibition constants of 0.67 mM and 0.45 mM, respectively. Addition of calf serum stimulated uptake of [3H]spermidine into the cells in a serum concentration-dependent manner. The effect was not observed when horse serum was used in place of calf serum. Preincubation of spermidine in calf serum for 1… CONTINUE READING
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