Serum deprivation induced autophagy and predominantly an AIF-dependent apoptosis in hippocampal HT22 neurons

@article{SteigerBarraissoul2009SerumDI,
  title={Serum deprivation induced autophagy and predominantly an AIF-dependent apoptosis in hippocampal HT22 neurons},
  author={S. Steiger-Barraissoul and Abdelhaq Rami},
  journal={Apoptosis},
  year={2009},
  volume={14},
  pages={1274-1288}
}
Neuronal death induced by serum deprivation (SD) in HT22-cells was accompanied by a moderate activation of caspase-3, a prominent upregulation of AIF and its translocation into the nucleus. In addition protein levels of autophagy markers such as LC3 and beclin-1 were affected by SD. The ratio of LC3-II/LC3-I was significantly increased in serum deprived… CONTINUE READING