Serum deoxythymidine kinase correlates with peripheral lymphocyte thymidine uptake in chronic lymphocytic leukemia

@article{Kllander1987SerumDK,
  title={Serum deoxythymidine kinase correlates with peripheral lymphocyte thymidine uptake in chronic lymphocytic leukemia},
  author={Clas F. R. K{\"a}llander and Bengt Simonsson and J. Simon Gronowitz and Kenneth Nilsson},
  journal={European Journal of Haematology},
  year={1987},
  volume={38}
}
The serum thymidine kinase (S‐TK) and proliferative activity of the leukemic cells were determined in 27 untreated patients with chronic lymphocytic leukemia (CLL). A significant positive correlation between S‐TK and proliferation expressed as a proliferative index (PI) was found (r = 0.70, p < 0.001). Additionally, PI (r = 0.59, p < 0.01) and S‐TK (r = 0.47, p < 0.05) correlated to peripheral blood lymphocyte count. When different variables and combinations of variables were studied in order… 

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Serum deoxythymidine kinase gives prognostic information in chronic lymphocytic leukemia

TLDR
It is concluded that S‐TK could be used as a prognostic marker for the individual CLL patient and seems to be useful for longitudinal follow‐up studies of disease status, both in indolent disease and in progressive disease during treatment.

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TLDR
The results indicate that determination of PI might be used as therapy guide since it was normalized during successful treatment and correlated well to variations in clinical disease activity in 8 patients examined at intervals during long term treatment.

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TLDR
It is concluded that s-dTk could be used both as a prognostic marker and to monitor the effect of therapy in NHL patients.

Evaluation of serum deoxythymidine kinase as a marker in multiple myeloma

TLDR
S‐TK correlated with the haemoglobin level but did not correlate with sex, age, erythrocyte sedimentation rate, nor with the serum concentrations of creatinine, β2‐microglobulin, Ca or M‐component.

Application of an in vitro assay for serum thymidine kinase: Results on viral disease and malignancies in humans

TLDR
The TK activity in sera from patients with both mononucleosis and tumor disease was characterized by electrophoresis and by its ability to utilize cytidine triphosphate as the phosphate donor, and showed that the serum TK has the same properties as the human cytosolar TK1, except in connection with varicella.

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TLDR
The demonstration of TK1 activity in the peripheral blood lymphocytes of clinically aggressive CLL suggests that this isoenzyme may be a useful biochemical marker of such behaviour.

Biochemical characteristics of chronic lymphocytic leukaemia. Glucocorticoid receptors, B and T lymphocyte surface markers, concanavalin A-induced agglutination and thymidine incorporation.

TLDR
5 out of 6 patients with progressive disease and 3 of 11 with nonprogressive disease had an increased proliferative index, indicating a correlation between this parameter and disease progression, and ConA agglutinability was not correlated to disease activity.

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TLDR
The development of a TK assay optimized for TK1, utilizing [1251] iododeoxyuridine as substrate, has been found to facilitate the detection of normal TK kinase activity.

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TLDR
It is concluded that bi‐weekly oral administration of chlorambucil is effective therapy for CLL with response rates similar to daily continuous chlor Ambucil.