Serum cytokine levels in response to hepatic cryoablation.

  title={Serum cytokine levels in response to hepatic cryoablation.},
  author={Shinji Osada and Hisashi Imai and Hiroyuki Tomita and Yasuharu Tokuyama and Naoki Okumura and Nobuhisa Matsuhashi and Fumio Sakashita and Kenichi Nonaka},
  journal={Journal of surgical oncology},
  volume={95 6},
BACKGROUND AND OBJECTIVES Cryogenic treatment sometimes stimulates the immune system by releasing intracellular antigens. We evaluated anti-tumor immune response by analyzing alterations in serum cytokine levels. METHODS Percutaneous cryosurgery was performed in 13 patients with unresectable tumors. Serum levels of interleukin (IL) -4, -6, and -10, tumor necrosis factor (TNF)-alpha, and interferon (IFN)-gamma were measured by enzyme-linked immunosorbent assay (ELISA). The Th1/Th2 ratio was… CONTINUE READING