Serum copper as a novel biomarker for resistance to thyroid hormone.

@article{Mittag2012SerumCA,
  title={Serum copper as a novel biomarker for resistance to thyroid hormone.},
  author={Jens Mittag and Thomas Behrends and Kristina Nordstr{\"o}m and Jo{\~a}o Anselmo and Björn Vennström and Lutz Schomburg},
  journal={The Biochemical journal},
  year={2012},
  volume={443 1},
  pages={
          103-9
        }
}
Thyroid hormone action is mediated by the thyroid hormone receptors TRα1 and TRβ. Defects in TRβ lead to RTH (resistance to thyroid hormone) β, a syndrome characterized by high levels of thyroid hormone and non-suppressed TSH (thyroid-stimulating hormone). However, a correct diagnosis of RTHβ patients is difficult as the clinical picture varies. A biochemical serum marker indicative of defects in TRβ signalling is needed and could simplify the diagnosis of RTHβ, in particular the… Expand
Unraveling the Molecular Basis for Successful Thyroid Hormone Replacement Therapy: The Need for New Thyroid Tissue- and Pathway-Specific Biomarkers.
TLDR
By comparing animal models to human data, the present minireview summarizes the status of this search for new tissue- and pathway-specific biomarkers of thyroid hormone action and suggests new biomarkers are urgently needed to improve the diagnostic management and monitor treatment efficiency. Expand
Positive correlation of thyroid hormones and serum copper in children with congenital hypothyroidism.
TLDR
The data highlight that serum Cu and thyroid hormones are strongly associated already in early postnatal life, and severely hypothyroid children are thus at risk of developing a Cu deficiency if not adequately nourished or supplemented. Expand
Growth hormone replacement may influence the biological action of thyroid hormone on liver and bone tissue.
  • N. Glynn, D. Halsall, +8 authors A. Agha
  • Medicine
  • Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society
  • 2021
TLDR
GH-induced alterations in the thyroid axis are associated with complex, tissue specific effects on thyroid hormone action and modulation of bone turnover markers suggests that GH may improve the biological action of thyroid hormone on bone. Expand
Biological significance of a thyroid hormone-regulated secretome.
TLDR
A detailed summary on the known secretory proteins regulated by T3 and their physiological significance is provided as part of a Special Issue entitled: An Updated Secretome. Expand
Association of maternal serum trace elements with newborn screening-thyroid stimulating hormone
TLDR
There was no significant association between most of the maternal serum trace elements and maternal thyroid hormone parameters, with an only exception between maternal Zn and maternal serum TSH. Expand
Inappropriate Secretion of TSH Syndrome
TLDR
The objective of this review is to properly characterize patients with a history of an affected first-degree relative, biochemical dynamic tests, pituitary imaging and genetic testing, according to what has been reported in international literature, and to analyze biochemical difficulties in choosing the best biochemical tools for that purpose. Expand
Selenium and Endocrine Tissues
TLDR
Notably, hypothalamus-pituitary-feedback regulation is responsive to Se, and the thyroid, islets of Langerhans in the pancreas, adrenal cortex, and gonads are strongly affected by Se status. Expand
An adult female with resistance to thyroid hormone mediated by defective thyroid hormone receptor α.
TLDR
Clinical and biochemical findings that are congruent with previous cases and newly recognized features in this adult female with defective TRα define a shared phenotype in TRα-mediated resistance to thyroid hormone, with differential tissue responses to T4 treatment. Expand
Exploring the role of copper and selenium in the maintenance of normal thyroid function among healthy Koreans.
TLDR
It is demonstrated that blood concentrations of copper and selenium were significantly associated with free T4 in healthy Korean subjects with sufficient iodine intake suggesting their role in maintaining normal thyroid function. Expand
Association of antiepileptic drug usage, trace elements and thyroid hormone status.
TLDR
AEDs were associated with serum Se and Cu levels, while serumSe and Cu were also associated with thyroid parameters, and subjects with ID did not display profound deficiencies in trace element levels. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 35 REFERENCES
Thyroid Hormones Regulate Selenoprotein Expression and Selenium Status in Mice
TLDR
Results show that TH positively affects the serum selenium status and regulates the expression of several selenoproteins, which demonstrates that seenium and TH metabolism are interconnected through a feed-forward regulation, which can in part explain the rapid parallel downregulation of both systems in critical illness. Expand
Approach to the patient with resistance to thyroid hormone and pregnancy.
TLDR
The mainstay in the management of RTH patients who are asymptomatic is to recognize the correct diagnosis and avoid antithyroid treatment, and whether to manage patients with TH replacement is made even more challenging when an affected individual is pregnant. Expand
Resistance to thyroid hormone.
  • S. Refetoff
  • Biology, Medicine
  • Current therapy in endocrinology and metabolism
  • 1997
TLDR
Clinical confirmation of the syndrome of resistance to thyroid hormone requires the demonstration of the failure of full replacement doses of thyroid hormone to produce the expected suppressive effect on the secretion of TSH and a failure to induce appropriate responses in peripheral tissues. Expand
Resistance to thyroid hormone is associated with raised energy expenditure, muscle mitochondrial uncoupling, and hyperphagia.
TLDR
It is demonstrated that basal mitochondrial substrate oxidation is increased and energy production in the form of ATP synthesis is decreased in the muscle of RTH patients and that resting oxidative phosphorylation is uncoupled in this disorder. Expand
A Thyroid Hormone Receptor α Gene Mutation (P398H) Is Associated with Visceral Adiposity and Impaired Catecholamine-stimulated Lipolysis in Mice*
TLDR
The TRα P398H mutation is associated with visceral adiposity and insulin resistance primarily due to a marked reduction in catecholamine-stimulated lipolysis, likely due to interference with TRα action as well as influence on other metabolic signaling pathways. Expand
Hypermetabolism in mice caused by the central action of an unliganded thyroid hormone receptor α1
TLDR
A novel and important role for the TRα1 aporeceptor in governing metabolic homeostasis is defined and it is demonstrated that a nuclear hormone receptor affecting sympathetic signaling can override its autonomous effects in peripheral tissues. Expand
[Hereditary thyroxin-binding globulin deficiency--changed thyroid function tests].
  • P. H. Kvistad, O. Myking
  • Medicine
  • Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke
  • 2001
TLDR
The condition is considered to represent X-chromosome linked inheritance with hemizygote affected males and heterozygote female carriers with intermediate values for T4 and TBG with a high level of measured FT4 combined with normal TSH is found; TBG deficiency should be considered. Expand
Molecular aspects of thyroid hormone actions.
TLDR
Genetically engineered knockin mouse models provide valuable tools to ascertain further the molecular actions of unliganded TRs in vivo that could underlie the pathogenesis of hypothyroidism. Expand
Study of trace elements in blood of thyroid disorder subjects before and after 131I therapy
TLDR
The results showed that the homeostasis of metal ions in both serum and erythrocyte could be more or less influenced by the altered thyroid hormones. Expand
Severe psychomotor and metabolic damages caused by a mutant thyroid hormone receptor alpha 1 in mice: can patients with a similar mutation be found and treated?
TLDR
Treatment of the mice with high doses of triiodothyronine leads to normalization or amelioration of the dysfunctions when applied at adequate developmental periods, akin to those seen in endemic cretinism and untreated congenital hypothyroidism. Expand
...
1
2
3
4
...