Serum concentrations of von Willebrand factor and soluble thrombomodulin indicate alteration of endothelial function in inflammatory bowel diseases

Abstract

Serum concentrations of immunoreactive von Willebrand factor (vWF) and soluble thrombomodulin (TM), and vWF multimer patterns were measured to assess endothelial function in patients with inflammatory intestinal diseases. In Crohn's disease and acute infective diarrhea, vWF concentrations were significantly higher than in normal controls. In all patient groups, multimeric analysis of vWF and the concentration of serum TM were not different from normal controls. The results indicate alteration of endothelial function in inflammatory intestinal disorders. They may be compatible with the presence of localized vasculitis, but indicate that systemic endothelial destruction does not occur in inflammatory bowel disease.

DOI: 10.1007/BF02064981

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Cite this paper

@article{Sawyerr1995SerumCO, title={Serum concentrations of von Willebrand factor and soluble thrombomodulin indicate alteration of endothelial function in inflammatory bowel diseases}, author={Dr. A. M. Sawyerr and BS M. S. Smith MB and A. Hall BSc and BS M. Hudson MB and C R M Hay and BS A. J. Wakefield MB and Michelle Brook and Hideaki Tomura and R. E. Pounder DSc}, journal={Digestive Diseases and Sciences}, year={1995}, volume={40}, pages={793-799} }