Serum concentrations of tramadol enantiomers during patient-controlled analgesia.

@article{Grond1999SerumCO,
  title={Serum concentrations of tramadol enantiomers during patient-controlled analgesia.},
  author={Stefan Grond and Th. Meuser and Heinz Uragg and Henning Stahlberg and Kirk A. Lehmann},
  journal={British journal of clinical pharmacology},
  year={1999},
  volume={48 2},
  pages={254-7}
}
AIMS Tramadol, a centrally acting analgesic, is used as a racemate containing 50% of a (+)- and 50% of a (-)-enantiomer. This paper presents the pharmacokinetic results of postoperative patient-controlled analgesia using (+)-tramadol, (-)-tramadol or the racemate. METHODS Ninety-eight patients recovering from major gynaecological surgery were treated in a randomised, double-blind study with (+)-tramadol, (-)-tramadol or the racemate. Following an i.v. bolus up to a maximum of 200 mg, patient… CONTINUE READING