Serum concentrations of tacrine hydrochloride predict its adverse effects in Alzheimer's disease.


OBJECTIVE To assess the value of serum measurements of tacrine hydrochloride and its metabolite in predicting risk of adverse reaction in Alzheimer's disease. METHODS The study was an outpatient-based controlled clinical trial. Study subjects were 35 female and 31 male patients who were receiving 50 to 150 mg tacrine hydrochloride per day. RESULTS Serum… (More)


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