Serum concentrations of organochlorine compounds and K-ras mutations in exocrine pancreatic cancer. PANKRAS II Study Group.

@article{Porta1999SerumCO,
  title={Serum concentrations of organochlorine compounds and K-ras mutations in exocrine pancreatic cancer. PANKRAS II Study Group.},
  author={Miquel Porta and N{\'u}ria Malats and Manuel Jariod and Joan O. Grimalt and Juli Rif{\'a} and Alfredo Carrato and Luisa Guarner and Antonio Soler Salas and Mary Santiago-Silva and Josep Mar{\'i}a Corominas and Montserrat Andreu and Francisco X Real},
  journal={Lancet},
  year={1999},
  volume={354 9196},
  pages={2125-9}
}
BACKGROUND Organochlorine compounds such as 1,1,1-trichloro-2,2-bis(p-chlorophenyl)-ethane (p,p'-DDT), 1,1-dichloro-2,2-bis(p-chlorophenyl) ethylene (p,p'-DDE), and some polychlorinated biphenyls (PCBs) are carcinogenic to animals and possibly also to human beings. Occupational exposure to DDT may increase the risk of pancreas cancer. The high frequency of K-ras mutations in pancreatic cancer remains unexplained. We analysed the relation between serum concentrations of selected organochlorine… CONTINUE READING
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