Serum concentrations of high-mobility group box chromosomal protein 1 before and after exposure to the surgical stress of thoracic esophagectomy: a predictor of clinical course after surgery?

@article{Suda2006SerumCO,
  title={Serum concentrations of high-mobility group box chromosomal protein 1 before and after exposure to the surgical stress of thoracic esophagectomy: a predictor of clinical course after surgery?},
  author={Koichi Suda and Yuko Kitagawa and Soji Ozawa and Yoshiro Saikawa and Michio Ueda and Edward Abraham and Masaki Kitajima and Akitoshi Ishizaka},
  journal={Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus},
  year={2006},
  volume={19 1},
  pages={5-9}
}
High-mobility group box chromosomal protein 1 (HMGB-1) has recently been shown as an important late mediator of endotoxin shock, intra-abdominal sepsis, and acute lung injury. However, its role in the systemic inflammatory response syndrome after major surgical stress, which may lead to multiple organ dysfunction syndrome, has not been thoroughly investigated. We hypothesized that serum HMGB-1 participates in the pathogenesis of postoperative organ system dysfunction after exposure to major… CONTINUE READING

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