Serum concentration of complement components of the lectin pathway in maintenance hemodialysis patients, and relatively higher levels of L-Ficolin and MASP-2 in Mannose-binding lectin deficiency.

@article{Ishii2011SerumCO,
  title={Serum concentration of complement components of the lectin pathway in maintenance hemodialysis patients, and relatively higher levels of L-Ficolin and MASP-2 in Mannose-binding lectin deficiency.},
  author={Masaya Ishii and Isao Ohsawa and Hiroyuki Inoshita and Gaku Kusaba and Kisara Onda and Michiro Wakabayashi and Hiroyuki Ohi and Satoshi Horikoshi and Misao Matsushita and Yasuhiko Tomino},
  journal={Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy},
  year={2011},
  volume={15 5},
  pages={441-7}
}
Mannose-binding lectin (MBL), L-ficolin and MBL associated serine protease-2 (MASP-2) are molecules involved in initiation of the lectin pathway (LP) in the complement system. Although MBL deficiency is observed in almost 10% of healthy people, studies of associations between MBL deficiency and end-stage renal disease (ESRD) remain rare. The objective of the present study is to clarify the significance of the LP in maintenance hemodialysis (HD) patients, especially in terms of MBL levels. Two… CONTINUE READING

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