Serum concentration of an inflammatory glycotoxin, methylglyoxal, is associated with increased cognitive decline in elderly individuals.

@article{Beeri2011SerumCO,
  title={Serum concentration of an inflammatory glycotoxin, methylglyoxal, is associated with increased cognitive decline in elderly individuals.},
  author={Michal Schnaider Beeri and Erin L. Moshier and James Schmeidler and James Godbold and Jaime Uribarri and Sarah Reddy and Mary Sano and Hillel T. Grossman and Weijing Cai and Helen Vlassara and Jeremy M. Silverman},
  journal={Mechanisms of ageing and development},
  year={2011},
  volume={132 11-12},
  pages={583-7}
}
BACKGROUND Advanced glycations end products increase oxidant stress, inflammation, and neurotoxicity. Serum levels are increased in diabetes and aging. We examined the relationship between serum methylglyoxal derivatives (sMG), and cognitive decline, in 267 non-demented elderly. METHODS Tobit mixed regression models assessed the association of baseline sMG with cognitive decline in the Mini Mental State Exam (MMSE) over time, controlling for sociodemographic factors (age, sex, and years of… CONTINUE READING
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