Serum chromogranin A as a screening test for gastric enterochromaffin-like cell hyperplasia during acid-suppressive therapy.

@article{Sanduleanu2001SerumCA,
  title={Serum chromogranin A as a screening test for gastric enterochromaffin-like cell hyperplasia during acid-suppressive therapy.},
  author={Silvia Sanduleanu and Adriaan P. de Bru{\"i}ne and Mats Stridsberg and Daisy M. A. E. Jonkers and Izak Biemond and Wim M Hameeteman and G{\"o}sta Lundqvist and Reinhold W. Stockbr{\"u}gger},
  journal={European journal of clinical investigation},
  year={2001},
  volume={31 9},
  pages={802-11}
}
BACKGROUND Serum chromogranin A (CgA), a marker of neuroendocrine neoplasia, increases during profound gastric acid inhibition, possibly reflecting the trophic effect of gastrin on the enterochromaffin-like (ECL) cells. AIMS This study investigated the clinical value of serum CgA as a screening test for gastric fundic enterochromaffin-like (ECL) cell hyperplasia during acid-suppressive therapy. METHOD A consecutive series of 230 dyspeptic patients referred for upper gastrointestinal… CONTINUE READING
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