Serum chemokine receptor CXCR3 ligands are associated with progression, organ dysfunction and complications of chronic liver diseases.

@article{Tacke2011SerumCR,
  title={Serum chemokine receptor CXCR3 ligands are associated with progression, organ dysfunction and complications of chronic liver diseases.},
  author={Frank Tacke and Henning Wolfgang Zimmermann and Mark E. Berres and Christian Trautwein and Hermann E. Wasmuth},
  journal={Liver international : official journal of the International Association for the Study of the Liver},
  year={2011},
  volume={31 6},
  pages={
          840-9
        }
}
BACKGROUND Chemokines are chemotactic mediators that are implicated in liver diseases. In viral hepatitis and primary biliary cirrhosis, a predominant chemokine receptor expressed in the liver is CXCR3, suggesting that its specific ligands are important in the progression of chronic liver diseases across different aetiologies. METHODOLOGY/PRINCIPAL FINDINGS We analysed the serum concentrations of the CXCR3 ligands, CXCL9 (monokine induced by interferon-γ), CXCL10 (interferon-γ-inducible… CONTINUE READING
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