Serum cathepsin K as a marker of bone metabolism in postmenopausal women treated with alendronate.

  title={Serum cathepsin K as a marker of bone metabolism in postmenopausal women treated with alendronate.},
  author={Manuel Mu{\~n}oz-Torres and Rebeca Reyes-Garc{\'i}a and Pedro Mezquita-Raya and Diego Fern{\'a}ndez-Garc{\'i}a and Guillermo Alonso and Juan de Dios Luna and Mar{\'i}a Estrella Ruiz-Requena and Fern{\'a}ndo Escobar-Jim{\'e}nez},
  volume={64 3},
CONTEXT Cathepsin K is a member of the cysteine protease family that cleaves both helical and telopeptide regions of collagen I, the major type of collagen in bone. Measurement of circulating levels of cathepsin K may be useful to assay the number or function of osteoclasts. OBJECTIVE The aim of the study was to evaluate the role of serum cathepsin K as a biochemical marker of bone metabolism in patients with postmenopausal osteoporosis before and after treatment with alendronate. DESIGN… CONTINUE READING


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