Serum carnitine and disabling fatigue in multiple sclerosis.

  title={Serum carnitine and disabling fatigue in multiple sclerosis.},
  author={Toshiyuki Fukazawa and Hidenao Sasaki and Seiji Kikuchi and Takeshi Hamada and Kunio Tashiro},
  journal={Psychiatry and clinical neurosciences},
  volume={50 6},
The serum concentrations of total, free and acylcarnitine were compared in 25 patients with multiple sclerosis (MS) and among age- and sex-matched normal controls by the new enzymatic cycling method in order to clarify whether the fatigue in MS might be due to possible carnitine-related fatty acid metabolic abnormalities in the mitochondria of skeletal muscles. Patients with MS were divided into those with and those without excessive fatigue. Levels of total and free carnitine were not… CONTINUE READING

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