Serum brain-derived neurotrophic factor predicts responses to escitalopram in chronic posttraumatic stress disorder.

@article{Berger2010SerumBN,
  title={Serum brain-derived neurotrophic factor predicts responses to escitalopram in chronic posttraumatic stress disorder.},
  author={William E Berger and Akhil Mehra and Maryann Lenoci and Thomas J. Metzler and Christian Otte and Gary Tarasovsky and S. Mellon and Owen M. Wolkowitz and Charles Marmar and Thomas C. Neylan},
  journal={Progress in neuro-psychopharmacology & biological psychiatry},
  year={2010},
  volume={34 7},
  pages={1279-84}
}
INTRODUCTION Some studies have found that antidepressants increase serum brain-derived neurotrophic factor (BDNF) levels in patients with major depression and the expression of BDNF mRNA in limbic structures of rats. OBJECTIVES This study addressed whether the SSRI escitalopram increases serum BDNF levels in subjects with PTSD and whether BDNF levels are associated with treatment response. METHODS Medically healthy male subjects (N=16) with chronic PTSD completed a 12 week open-label trial… CONTINUE READING