Serum bone alkaline phosphatase isoenzyme levels in normal children and children with growth hormone (GH) deficiency: a potential marker for bone formation and response to GH therapy.

@article{Tobiume1997SerumBA,
  title={Serum bone alkaline phosphatase isoenzyme levels in normal children and children with growth hormone (GH) deficiency: a potential marker for bone formation and response to GH therapy.},
  author={H Tobiume and Susumu Kanzaki and Shuichi Hida and Takuya Ono and Tadashi Moriwake and Shuhei Yamauchi and Hiroyuki Tanaka and Yoshiki Seino},
  journal={The Journal of clinical endocrinology and metabolism},
  year={1997},
  volume={82 7},
  pages={2056-61}
}
Serum bone alkaline phosphatase (B-ALP) has been considered to be a good marker for bone formation. Recently, a specific immunoradiometric assay for serum B-ALP has been developed. Using this system, we measured the serum levels of B-ALP in 363 normal children (207 males and 156 females, age 0-18 yr) and in 20 GH-deficient children (age 5-13 yr) who showed significant bone growth during GH therapy. We found the following results. 1) There were no significant circadian variations in serum B-ALP… CONTINUE READING
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