Serum bone Gla protein as a marker of bone turnover in acromegaly

  title={Serum bone Gla protein as a marker of bone turnover in acromegaly},
  author={M Ant{\'o}n Marazuela and B. Astigarraga and Ma Jos{\'e} Tabuenca and Jaime Estrada and Fernando Azor{\'i}n Mar{\'i}n and Tanya Lucas},
  journal={Calcified Tissue International},
Serum bone Gla protein, a sensitive and specific marker of bone turnover, was measured in 35 acromegalic patients (14 untreated, 8 clinically active, and 13 cured) and 21 controls. We also examined 10 acromegalic patients before and after transsphenoidal surgery. Untreated and clinically active acromegalic patients had significantly higher serum bone Gla protein concentrations than the control subjects. Other nonspecific biochemical markers of bone metabolism, such as urinary hydroxyproline and… CONTINUE READING


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