Serum biomarkers as predictors of lung function decline in chronic obstructive pulmonary disease.

@article{Higashimoto2009SerumBA,
  title={Serum biomarkers as predictors of lung function decline in chronic obstructive pulmonary disease.},
  author={Yuji Higashimoto and Takuya Iwata and Morihiro Okada and Hiroaki Satoh and Kanji Fukuda and Yuji Tohda},
  journal={Respiratory medicine},
  year={2009},
  volume={103 8},
  pages={1231-8}
}
BACKGROUND Recent studies show that COPD patients exhibit low-grade systemic inflammation, and that plasma fibrinogen and high neutrophil counts are related to faster declines in lung function. We examined correlations between serum biomarkers and the decline of lung function in COPD patients. METHOD Baseline levels of 9 serum biomarkers (TIMP-1, alpha1-antitrypsin, MMP-9, TNF-alpha, TGF-beta, IL-6, IL-8, neutrophil elastase and CRP), fibrinogen and white blood cell counts (WCC) were measured… CONTINUE READING

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