Serum bilirubin levels in the U.S. Population: Gender effect and inverse correlation with colorectal cancer

  title={Serum bilirubin levels in the U.S. Population: Gender effect and inverse correlation with colorectal cancer},
  author={Stephen D. Zucker and Paul S. Horn and Kenneth E. Sherman},
Bilirubin, the primary end product of heme catabolism, is a key marker of liver and hematological disorders, and important cytoprotective properties have been ascribed to this bile pigment. The Third National Health and Nutrition Examination Survey, a comprehensive assessment of health and nutrition in the United States, was analyzed to determine the demographics and correlates of serum bilirubin levels in the general population. Men and women aged 17 and older were included in the weighted… 

The Bilirubin Level is Negatively Correlated with the Incidence of Hypertension in Normotensive Korean Population

A mild increase within the physiological range of serum bilirubin concentration was negatively correlated with the incidence of hypertension, and the effect of bilirube on the development of hypertension was more evident in females and in non-smokers.

Serum bilirubin concentration in patients with an established coronary artery disease.

Reduced serum levels of bilirubin were shown to be associated with a higher prevalence of coronary artery disease emerging as a new potential risk factor marker.

Impact of Serum Bilirubin on Human Diseases

Current knowledge of all the aspects of this topic almost completely is covered, and more data that further support a salutary role of bilirubin in the human body are mentioned.

Albumin, bilirubin, uric acid and cancer risk: results from a prospective population-based study

It is indicated that higher levels of albumin and uric acid are related to lower risks of breast cancer and cancer mortality and further studies are needed to assess whether the observed associations are causal.

Correlations between the serum bilirubin level and ulcerative colitis: a case–control study

TBIL and especially IBIL may be independent protective factors for UC because of their antioxidant and anti-inflammatory effects.

Behavioral and clinical correlates of serum bilirubin concentrations in Japanese men and women

Serum HDL cholesterol was a measurable clinical correlate of bilirubin in women and smoking, alcohol use and coffee consumption were important behavioral correlates of serum bilirUBin in Japanese men and women.

Looking to the horizon: the role of bilirubin in the development and prevention of age-related chronic diseases.

Evidence is suggested to suggest that bilirubin is a biomarker for reduced chronic disease prevalence and a predictor of all-cause mortality, which is of important clinical significance, and should be considered more carefully in clinical practice.

Lower serum levels of bilirubin in the newly diagnosed lung cancer patients: A case-control study in China.

Lower levels of bilirubin may be a risk factor for lung cancer, and it could serve as a potential screening biomarker for lung cancers, according to this study.



Serum bilirubin and 10-year mortality risk in a Belgian population

In this population high serum bilirubin, however, within normal ranges, was associated with low cancer mortality, especially in men, which may be due to the antioxidant activity of bilirUBin.

Serum levels of micronutrients, antioxidants and total antioxidant status predict risk of breast cancer in a case control study.

It is concluded that increased serum levels of beta-carotene, retinol, bilirubin and total antioxidant status are associated with reductions in breast cancer risk.

Influence of Sex and Age on the Normal Range of Eleven Serum Constituents

Serum concentrations of calcium, inorganic phosphorus, total protein, albumin, urea nitrogen, uric acid, cholesterol, total bilirubin, alkaline phosphatase and serum aspartate transaminase were measured in a large ambulatory population to provide normal values according to sex and age.

Serum bilirubin and risk of ischemic heart disease in middle-aged British men.

The significance of this U-shaped relationship between serum bilirubin and risk of ischemic heart disease is unclear, but it could be interpreted as support for the role of endogenous antioxidants in the etiology of IHD.

Serum bilirubin concentration in a Belgian population: the association with smoking status and type of cigarettes.

The duration of smoking is a more important determinant for serum bilirubin concentrations than the number of cigarettes smoked per day, which may indicate the cumulative negative effects of smoking on the endogenous antioxidant system.

Racial differences in serum total bilirubin levels in health and in disease (pernicious anemia).

It is suggested that the lower serum bilirubin levels in blacks in health and disease do not stem primarily from lower bilirubsin production than in whites, but rather from racial differences that were maintained in pernicious anemia.

Association of low serum concentration of bilirubin with increased risk of coronary artery disease.

It is suggested that serum bilirubin is an inverse and independent risk factor for CAD, with an association equivalent in degree to that of systolic blood pressure.

Population studies on Gilbert's syndrome.

The mean bilirubin concentration was significantly lower in the females than in the males, suggesting that the population incidence of Gilbert's syndrome could be as high as 6% and that the sex incidence is approximately equal.