Evaluation of clinical usefulness of serum neopterin determination in children with bacterial infections.
The aim of this study is to evaluate serum beta 2-microglobulin and neopterin levels in children with febrile illness and to clarify their relation to influenza and febrile seizures (FS). We studied 34 patients with febrile illness whose age was between 1 and 6 years. Influenza A antigen in the throat swab was positive in 17 patients (Flu group) and was negative in 17 (control group). Serum levels of beta 2-microglobulin and neopterin were evaluated on admission. FS were observed in 13 patients (6 in Flu group and 7 in control group). Serum beta 2-microglobulin and neopterin levels were higher in Flu group than in control group. On the other hand, there were no significant differences in serum beta 2-microglobulin or neopterin levels between those with and without FS. Higher serum beta 2microglobulin and neopterin levels in Flu group suggested that stronger activation of immune system was caused by influenza than by infection with other agents. (J Pediatr Neurol 2003; 1(1): 35-38).