Serum bactericidal and opsonic activities in chronic lymphocytic leukemia and multiple myeloma

  title={Serum bactericidal and opsonic activities in chronic lymphocytic leukemia and multiple myeloma},
  author={E. Kansu and E. Akalin and Cahid A. Civelek and O. Tekeşin and Yahya Lalell and D. Firat},
  journal={American Journal of Hematology},
Susceptibility to infection is widely recognized as the major cause of morbidity and mortality in patients with CLL and MM. The present study was designed to investigate the serum bactericidal (SBA) and serum opsonic activities (SOA) in 12 CLL and 12 MM patients, and results were compared to 20 normals. SBA and SOA were measured by a new radiometric assay. SBA was found to be normal in 11 patients with CLL and in all 12 patients with MM. In contrast, SOA was significantly lower in 11 out of 12… Expand
Chemiluminescence response of polymorphonuclear leucocytes to serum-opsonized zymosan--a predictive parameter for infections and prognosis in multiple myeloma patients.
A defect in MM and CLL sera opsonization ability is suggested which, at least in part, could account for the increased susceptibility to infections observed in patients with multiple myeloma and chronic lymphocytic leukaemia. Expand
Functional abnormalities in granulocytes predict susceptibility to bacterial infections in chronic lymphocytic leukaemia
Impaired granulocyte functions contribute to susceptibility to infections in CLL, and lymphocyte functions (mitogen‐induced lymphocyte proliferation and immunoglobulin production in vitro) were equally impaired in all patients with CLL. Expand
Impaired bactericidal but not fungicidal activity of polymorphonuclear neutrophils in patients with chronic lymphocytic leukemia
Differences in PMN microbicidal response against A. fumigatus in patients with CLL were associated with the degree of hypogammaglobulinemia, and compared to patients with effective PMN responses, they were not identified. Expand
Multiple myeloma presenting with an acute bacterial infection
MM should be considered in previously asymptomatic middle‐aged patients who present with a major acute bacterial infection, without an apparent predisposing factor, in particular, suspicion should be high in cases of septic arthritis and pneumococcaemia. Expand
Renal, hematologic and infectious complications in multiple myeloma.
Renal replacement with dialysis is a worthwhile measure in patients with end-stage renal failure, and high-dose therapy/autologous transplant may be of benefit in selected patients. Expand
Plasma cell dyscrasias: current status.
This is a review of the current status of the monoclonal gammopathies (plasma cell dyscrasias) and diagnosis and treatment of Waldenström's macroglobulinemia are presented. Expand
[Multiple myeloma and infection].
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Defective opsonization in multiple myeloma.
The data suggest that MM serum lacks both heat-stable and heat-labile opsonic activity, and support the concept that defective host resistance in MM may be multifactoral, combining o Simpsonic abnormalities with other defects previously described. Expand
Bactericidal and opsonic activity of ascitic fluid from cirrhotic and noncirrhotic patients.
It is demonstrated that noncirrhotic ascitic fluid has antibacterial activity similar to normal peritoneal fluid, whereas cirrhotic Ascension fluid has a marked reduction of both bactericidal and opsonic activities. Expand
Impaired antibody response and low levels of normal gamma globulin components indicate that reduction of normal plasma cell function is a prominent feature in multiple myeloma and macroglobulinemia and appears to reflect some other feature of plasmacytic and lymphocytic malignancy. Expand
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Impaired antibody production may be the major immune defect leading to S. pneumoniae and H. influenzae infections whereas some additional factor or factors related to disease activity appear to predispose to gram-negative infection in myeloma. Expand
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The normal serum bactericidal systems were characterized in terms of activity against rough- and smooth-phase species of gram-negative bacteria, indicating that the natural antibodies in normal serum were specific for surface antigens other than the O-somatic polysaccharides. Expand
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The clinical, laboratory and pathologic findings were studied in 62 consecutively autopsied patients with multiple myeloma between 1954 and 1975, finding a good response to alkylating agent therapy, initial BUN less than 40 mg/dl and serum calcium less than 12mg/dl were favorable to prognostic indicators. Expand
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There are a number of different clinical situations in which an increased susceptibility to infection is associated with decreased serum opsonizing activity, which serve to illustrate the important role opsonins play in the host's resistance to infection. Expand
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An elderly man with CLL who had repeated, severe bacterial and fungal infections including recurrent cryptococcal meningitis, disseminated histoplasmosis, Vibrio fetus sepsis, Pasturella tularensis sepsi, and Aspergillus pneumonia is described. Expand