Serum bactericidal and opsonic activities in chronic lymphocytic leukemia and multiple myeloma

@article{Kansu1986SerumBA,
  title={Serum bactericidal and opsonic activities in chronic lymphocytic leukemia and multiple myeloma},
  author={E. Kansu and E. Akalin and Cahid A. Civelek and O. Tekeşin and Yahya Lalell and D. Firat},
  journal={American Journal of Hematology},
  year={1986},
  volume={23}
}
Susceptibility to infection is widely recognized as the major cause of morbidity and mortality in patients with CLL and MM. The present study was designed to investigate the serum bactericidal (SBA) and serum opsonic activities (SOA) in 12 CLL and 12 MM patients, and results were compared to 20 normals. SBA and SOA were measured by a new radiometric assay. SBA was found to be normal in 11 patients with CLL and in all 12 patients with MM. In contrast, SOA was significantly lower in 11 out of 12… Expand
Chemiluminescence response of polymorphonuclear leucocytes to serum-opsonized zymosan--a predictive parameter for infections and prognosis in multiple myeloma patients.
TLDR
A defect in MM and CLL sera opsonization ability is suggested which, at least in part, could account for the increased susceptibility to infections observed in patients with multiple myeloma and chronic lymphocytic leukaemia. Expand
Functional abnormalities in granulocytes predict susceptibility to bacterial infections in chronic lymphocytic leukaemia
TLDR
Impaired granulocyte functions contribute to susceptibility to infections in CLL, and lymphocyte functions (mitogen‐induced lymphocyte proliferation and immunoglobulin production in vitro) were equally impaired in all patients with CLL. Expand
Impaired bactericidal but not fungicidal activity of polymorphonuclear neutrophils in patients with chronic lymphocytic leukemia
TLDR
Differences in PMN microbicidal response against A. fumigatus in patients with CLL were associated with the degree of hypogammaglobulinemia, and compared to patients with effective PMN responses, they were not identified. Expand
Multiple myeloma presenting with an acute bacterial infection
TLDR
MM should be considered in previously asymptomatic middle‐aged patients who present with a major acute bacterial infection, without an apparent predisposing factor, in particular, suspicion should be high in cases of septic arthritis and pneumococcaemia. Expand
Renal, hematologic and infectious complications in multiple myeloma.
TLDR
Renal replacement with dialysis is a worthwhile measure in patients with end-stage renal failure, and high-dose therapy/autologous transplant may be of benefit in selected patients. Expand
Plasma cell dyscrasias: current status.
TLDR
This is a review of the current status of the monoclonal gammopathies (plasma cell dyscrasias) and diagnosis and treatment of Waldenström's macroglobulinemia are presented. Expand
[Multiple myeloma and infection].
  • A. Togawa
  • Medicine
  • Nihon Rinsho Men'eki Gakkai kaishi = Japanese journal of clinical immunology
  • 1998

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