Serum bactericidal activity of ceftazidime: continuous infusion versus intermittent injections.

@article{Nicolau1996SerumBA,
  title={Serum bactericidal activity of ceftazidime: continuous infusion versus intermittent injections.},
  author={David P Nicolau and Charles H. Nightingale and Mary Anne Banevicius and Qiang Fu and Richard Quintiliani},
  journal={Antimicrobial agents and chemotherapy},
  year={1996},
  volume={40 1},
  pages={61-4}
}
Since beta-lactam antibiotics have concentration-independent killing, bacterial eradication is a function of the time the serum drug concentration remains above the drug's MIC (T > MIC). We compared the serum bactericidal titers (SBTs) of ceftazidime given by continuous infusion (CI) or by intermittent bolus dosing (BD) against two clinical isolates each of Pseudomonas aeruginosa and Escherichia coli to determine if CI would allow lower daily dosing while still providing equal bactericidal… CONTINUE READING

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