Serum autoantibodies recognizing 5-hydroxymethyl-2'-deoxyuridine, an oxidized DNA base, as biomarkers of cancer risk in women.

@article{Frenkel1998SerumAR,
  title={Serum autoantibodies recognizing 5-hydroxymethyl-2'-deoxyuridine, an oxidized DNA base, as biomarkers of cancer risk in women.},
  author={Krystyna Frenkel and Jerzy Karkoszka and Tavis Jared Glassman and Neil Dubin and Paolo G. Toniolo and Emanuela Taioli and LaVerne A Mooney and Ikuko Kato},
  journal={Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology},
  year={1998},
  volume={7 1},
  pages={49-57}
}
Human sera contain anti-5-hydroxymethyl-2'-deoxyuridine (HMdU; an oxidized thymidine) autoantibodies (aAbs), which are significantly higher in chronic inflammatory diseases. The intent of this study was to establish whether anti-HMdU aAbs can serve as predictors of breast and colorectal cancer risk. Sera of 169 women were analyzed by ELISA. Women healthy at blood donation but who were diagnosed 0.5-6 years later with breast or colorectal cancer exhibited significantly increased anti-HMdU aAbs… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 22 extracted citations

Levels of 5-hydroxymethyl-2'-deoxyuridine in DNA from blood of women scheduled for breast biopsy.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology • 2001
View 4 Excerpts
Highly Influenced

Autoimmunity and cancer.

Asian Pacific journal of cancer prevention : APJCP • 2012
View 1 Excerpt

Similar Papers

Loading similar papers…