Serum autoantibodies in chronic hepatitis C: Comparison with autoimmune hepatitis and impact on the disease profile

  title={Serum autoantibodies in chronic hepatitis C: Comparison with autoimmune hepatitis and impact on the disease profile},
  author={Fabio Cassani and Michela Cataleta and Paolo Valentini and Paolo Muratori and Fabrizio Giostra and Raffaella Francesconi and Luigi Muratori and Marco Lenzi and Giampaolo Bianchi and Daniela Zauli and Fb. Bianchi},
Antibodies to nuclei (ANA), smooth muscle (SMA), and liver/kidney microsomes type 1 (anti‐LKM1) may occur in chronic hepatitis C. Distinct subspecificities, including ANA with the homogeneous pattern (ANA‐H) and SMA with antiactin specificity (SMA‐AA), are found in autoimmune hepatitis (AIH). This study was performed to characterize the hepatitis C virus (HCV)‐associated autoantibodies and to evaluate their influence on the profile of the disease. Two hundred ninety consecutive patients with… 
Autoantibody profiles in autoimmune hepatitis and chronic hepatitis C identifies similarities in patients with severe disease
It was found that AIH patients had more severe liver disease as determined by elevation of total IgG, alkaline phosphatase, total serum bilirubin and serum transaminases and significantly higher prevalence of the three non-organ-specific autoantibodies (auto-Abs) than CHC patients.
Auto-antibodies in hepatitis C.
Autoantibodies in chronic liver disease.
The co-existence of HCV infection and autoimmune hepatitis should be considered in patients who are positive for both viral markers and autoantibodies and thorough evaluation of patients must be performed before selection of treatment.
Autoantibody profile in individuals with chronic hepatitis C.
In addition to the high prevalence of autoantibodies associated with HCV infection, it was observed that NOSA positivity was associated with a more severe histological and biochemical profile of hepatitis C infection.
A comparison of the prevalence of anti-Liver/Kidney Microsome antibody type-1(LKM-1) in individuals with chronic hepatitis C and those with autoimmune hepatitis
Patients with autoimmune hepatitis are more commonly women than those with chronic viral hepatitis, and they have higher serum levels of aspartate aminotransferase, bilirubin, gamma-globulin, IgG, alkaline phosphates, and higher frequency of multilobular necrosis on histologic examination than counters with Chronic viral hepatitis.
Smooth Muscle Antibodies and Type 1 Autoimmune Hepatitis
SMA-T pattern is highly sensitive and specific first diagnostic test for type 1 AIH; anti-MF can be used as additional tool for the diagnosis, particularly when, despite the absence of the SMA-t pattern, AIH is strongly suspected.
Autoimmune Hepatitis: Serum Autoantibodies in Clinical Practice
The reference method for autoantibody testing remains indirect immunofluorescence on triple tissue, allowing both the detection of the majority of liver-relevant reactivities, including thoseAutoantibodies whose molecular target antigens are unknown.
Autoantibodies and autoantigens in autoimmune hepatitis: important tools in clinical practice and to study pathogenesis of the disease
The expression of CYP2D6 on the surface of hepatocytes suggesting a pathogenetic role of anti-LKM-1 autoantibodies for the liver damage is demonstrated, and the distinction between AIH and chronic viral hepatitis (especially of HCV) is of particular importance.
Is autoimmune hepatitis a frequent finding among HCV patients with intense interface hepatitis?
Although possible, overlap with autoimmune hepatitis is a very rare association in HCV-infected patients with intense interface hepatitis, an unusual presentation which seems to be related to other host variables.
Current status of autoimmune hepatitis in Japan.
Recently, the number of atypical cases lacking the usual features has increased--for example, patients with acute-onset or fulminant-type AIH, autoantibody-negative patients, male patients, and patients with bile duct injury--and thus the clinical features of AIH have been diversified, and persistent normalization of transaminase is required.


Serum autoantibodies and the diagnosis of type-1 autoimmune hepatitis in Italy: a reappraisal at the light of hepatitis C virus infection.
The detection of ANA-H or SMA-AA, in fact, identifies chronic liver disease patients with a relatively low prevalence of antihepatitis C virus, but does not exclude hepatitis C virus infection.
Heterogeneity of liver/kidney microsomal antibody type 1 in autoimmune hepatitis and hepatitis C virus related liver disease.
Reactivity to CYP2D6 and its amino acid sequence 257-269 was significantly more common in autoimmune hepatitis than in HCV infected patients, while sera from patients with HCV infection are more likely to recognise other microsomal targets, the molecular identity of which is currently unknown.
High prevalence of serological markers of autoimmunity in patients with chronic hepatitis C
It is concluded that markers of autoimmunity occur with high and equal frequency in men and women with chronic hepatitis C and should not preclude therapy with IFN, which often improves hepatitis and features of autoimmune disease in patients with both.
Immunological disorders in C virus chronic active hepatitis: A prospective case‐control study
The prevalences of cryoglobulinemia, rheumatoid factor and antitissue antibodies were significantly higher than those in the control group and patients with chronic hepatitis B, and can be classified into several categories.
Precipitating antibodies to rabbit thymus extractable antigens in chronic liver disease: relationship with anti-actin antibodies.
Using counterimmunoelectrophoresis (CIE), serum antibodies to rabbit thymus extractable antigens were detected in 15% (38/259) of patients with chronic liver disease (CLD) of various aetiologies and
Extrahepatic Immunologic Manifestations in Chronic Hepatitis C and Hepatitis C Virus Serotypes
A serotyping assay was used to study whether the occurrence of extrahepatic immunologic abnormalities in patients with chronic hepatitis C is serotype dependent, and several studies indicate that particular HCV genotypes are associated with more severe liver disease and poorer response to interferon- therapy.