Serum asymmetric dimethylarginine (ADMA), homocysteine, vitamin B12, folate levels, and lipid profiles in epileptic children treated with valproic acid

@article{Ozdemir2010SerumAD,
  title={Serum asymmetric dimethylarginine (ADMA), homocysteine, vitamin B12, folate levels, and lipid profiles in epileptic children treated with valproic acid},
  author={Ozlem Kumbasar Ozdemir and Ayten Yakut and Ener Cagri Dinleyici and Sultan Durmuş Aydoğdu and Coşkun Yarar and Omer Faruk Colak},
  journal={European Journal of Pediatrics},
  year={2010},
  volume={170},
  pages={873-877}
}
Recent reports have demonstrated elevated serum homocysteine (Hcy) levels in children receiving valproic acid (VPA) therapy. Elevated Hcy levels might play a potential role in the resistance to antiepileptic drugs, and might lead to an increased risk for a vascular disease. It has been reported that elevated total homocysteine (tHcy) levels are associated with elevated asymmetric dimethylarginine (ADMA) levels, which are factors that may be better indicators of endothelial dysfunction compared… CONTINUE READING
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