Serum anti-osteopontin autoantibody as a novel diagnostic and prognostic biomarker in patients with hepatocellular carcinoma.

  title={Serum anti-osteopontin autoantibody as a novel diagnostic and prognostic biomarker in patients with hepatocellular carcinoma.},
  author={Xia Ying and Yue-kun Zhao and Jun-lan Wang and Xia Zhou and Jing Zhao and Chenchen He and Xi-jing Guo and Gui-hua Jin and Li-juan Wang and Qing Zhu and Suxia Han},
  journal={Oncology reports},
  volume={32 4},
Osteopontin (OPN) is a secreted phosphorylated and glycosylated protein, which plays an important role in carcinogenesis and metastasis. In hepatocellular carcinoma (HCC), OPN is being investigated either as a therapeutic target gene or as a biomarker for diagnosis. Yet, the role of the anti-OPN autoantibody in HCC remains unclear. In the present study, the level of serum anti-OPN autoantibody in HCC was analyzed by enzyme-linked immunosorbent assay. Immunohistochemistry (IHC) was also… 

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