Serum angiotensin-converting enzyme levels in patients with recent-onset insulin-dependent diabetes after one year of low-dose cyclosporin therapy. IMDIAB Study Group.

@article{Letizia1995SerumAE,
  title={Serum angiotensin-converting enzyme levels in patients with recent-onset insulin-dependent diabetes after one year of low-dose cyclosporin therapy. IMDIAB Study Group.},
  author={Claudio Letizia and Cecilia D'Ambrosio and A De Ciocchis and David Scavo and Paolo Pozzilli},
  journal={International journal of clinical pharmacology research},
  year={1995},
  volume={15 5-6},
  pages={209-13}
}
Cyclosporin A (CyA) is today used for the treatment of autoimmune diseases and in the past was given also to patients with recent-onset insulin-dependent diabetes mellitus (IDDM). Hypertension is a major hazard in patients receiving CyA. In this study we have evaluated the effect of CyA administered to IDDM patients on blood pressure and serum angiotensin-converting enzyme (SACE), an endopeptidase that is an integral part of the renin-angiotensin and bradykinin systems. Sera from patients… CONTINUE READING