Serum angiopoietin-2 levels are elevated during acute exacerbations of COPD.

  title={Serum angiopoietin-2 levels are elevated during acute exacerbations of COPD.},
  author={Yu Ji Cho and Jeong Eun Ma and Eun Young Yun and Yu Eun Kim and Ho Cheol Kim and Jong Deog Lee and Young Sil Hwang and Yi Yeong Jeong},
  volume={16 2},
BACKGROUND AND OBJECTIVE Recently, angiopoietin-2 (Ang-2) was identified as a ligand of the endothelial receptor tyrosine kinase, Tie-2. Ang-2 is an angiopoietin-1 antagonist that plays a role in vascular destabilization and remodelling, which may increase in some diseases. However, serum Ang-2 levels have not been evaluated in patients with COPD. In this study, we examined serum Ang-2 concentrations in patients experiencing COPD exacerbations and in patients with stable COPD. METHODS Serum… CONTINUE READING


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