Serum and tissue levels of teicoplanin during cardiac surgery: the effect of a high dose regimen.

@article{Wilson1989SerumAT,
  title={Serum and tissue levels of teicoplanin during cardiac surgery: the effect of a high dose regimen.},
  author={A. Peter R. Wilson and S. Raja Shankar and David Felmingham and Tom Treasure and Reuben N. Gr{\"u}neberg},
  journal={The Journal of antimicrobial chemotherapy},
  year={1989},
  volume={23 4},
  pages={613-7}
}
Two prospective trials suggested that teicoplanin was less effective in preventing Gram-positive wound infections after cardiac surgery than a combination of flucloxacillin and an aminoglycoside. The initial dose of 400 mg was associated with a subinhibitory concentration of teicoplanin in fat at the end of operation. In this study, the behaviour of a higher initial dose (12 mg/kg) was investigated in ten patients during coronary artery surgery. As in the earlier trials, a second dose (400 mg… CONTINUE READING