Serum and synovial fluid levels of p40 IL12/23 in spondyloarthropathy patients

@article{Wendling2008SerumAS,
  title={Serum and synovial fluid levels of p40 IL12/23 in spondyloarthropathy patients},
  author={Daniel Wendling and Jean-Pierre C{\'e}doz and Evelyne Racadot},
  journal={Clinical Rheumatology},
  year={2008},
  volume={28},
  pages={187-190}
}
IL-23 is the main inductor in Th17 polarization of naive T cells, inducing IL-17 production. IL-17 has been demonstrated to be elevated in ankylosing spondylitis (AS). The p40 subunit is common to IL-12 and IL-23. We assessed serum and synovial levels of p40 IL12/23 in spondyloarthropathy (SpA) patients and the evolution under anti-TNF. SpA patients fulfilling ESSG criteria were included. Healthy volunteers served as controls. P40 IL12/23 was assessed using Human Quantikine ELISA (R&D Systems… CONTINUE READING